Citation Metadata
| Persistent Identifier | doi:10.34894/FCBXSI |
| Publication Date | 2024-11-20 |
| Title | SMART-Youth: Data |
| Subtitle | SMART-Youth: Secondary Manifestations of ARTerial diseases in the Young with a chronic condition |
| Author | Isabelle van der Linden (UMC Utrecht) - ORCID |
| Henk Schipper (Erasmus MC) - ORCID | |
| Sanne Nijhof (UMC Utrecht) - ORCID | |
| Kors van der Ent (UMC Utrecht) - ORCID | |
| Point of Contact | Isabelle van der Linden (UMC Utrecht) |
| Datamanagement Pediatrics (UMC Utrecht) | |
| Description | Rationale: The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study established that atherogenesis starts in childhood, initiating in the iliac arteries and abdominal aorta and subsequently develops in higher regions of the arterial tree. Childhood and adolescence thereby provide a unique window of opportunity to prevent atherosclerotic cardiovascular disease (ASCVD) later in life, especially for pediatric groups at risk. The growing list of pediatric groups at risk includes chronic inflammatory disorders, organ transplant recipients, familial hypercholesterolemia, endocrine disorders, childhood cancer survivors, chronic kidney diseases, congenital heart diseases, fetal growth restriction, and premature birth, next to increasing numbers of children and adolescents with traditional risk factors such as obesity, hypertension, hyperlipidemia, and hyperglycemia. The best way to assess cardiovascular health in the pediatric population is relatively unchartered territory. Multisite and multimodal assessment of early atherosclerosis emerged as the best way to capture the complexity of atherosclerosis as a systemic disease. Next to conventional carotid intima-media thickness measurements, implementation of aortic pulse wave velocity and endothelial function measurements can advance the assessment of early atherosclerosis in pediatrics. Objective: The primary objective of this study is to establish the effect of disease and lifestyle associated cardiovascular risk factors on preclinical atherosclerosis in children with a chronic condition, and follow this up over time. Study design: The SMART-Youth study is a prospective, longitudinal cohort study including children with various chronic conditions followed up in the Wilhelmina Children’s Hospital. Study population: Children with various chronic conditions who are enrolled in the PROactive study, within the age range of 8-18 years. The study will include the following chronic conditions: cystic fibrosis, juvenile idiopathic arthritis, systemic autoimmune diseases, chronic kidney disease, primary immunodeficiency, autoinflammatory conditions, inflammatory bowel disease, and congenital heart disease, as well as children with a history of premature birth or fetal growth restriction, and children with persistent somatic symptoms. The total expected inclusion rate entails 1350 subjects within five years. Main study parameters/endpoints: Carotid Intima Media Thickness (cIMT) and Aortic pulse wave velocity (PWV) as preclinical atherosclerosis outcomes. (2024-11-08) |
| Subject | Medicine, Health and Life Sciences |
| Keyword | Chronic Disease (MeSH) |
| Child Health (MeSH) | |
| Cardiometabolic Risk Factors (MeSH) | |
| Atherosclerosis (MeSH) | |
| Topic Classification | Atherosclerosis (MeSH) |
| Related Publication | Nijhof, S., van de Putte, E., & Hoefnagels, J. W. (2021). PROactive Cohort Study: Data (Version 8) [Dataset]. DataverseNL. https://doi.org/10.34894/FXUGHW |
| Katier, N., Uiterwaal, C. S., de Jong, B. M., Kimpen, J. L., Verheij, T. J., Grobbee, D. E., Brunekreef, B., Numans, M. E., & van der Ent, C. K. (2004). The Wheezing Illnesses Study Leidsche Rijn (WHISTLER): Rationale and design. European Journal of Epidemiology, 19(9), 895–903. https://doi.org/10.1023/b:ejep.0000040530.98310.0c | |
| Ververs, F. A., Eikendal, A. L. M., Kofink, D., Nuboer, R., Westenberg, J. J. M., Hovenkamp, G. T., Kemps, J. J. A., Coenen, I. C. J., Daems, J. J. N., Claus, L. R., Ju, Y., Wulffraat, N. M., van der Ent, C. K., Monaco, C., Boes, M., Leiner, T., Grotenhuis, H. B., & Schipper, H. S. (2022). Preclinical aortic atherosclerosis in adolescents with chronic disease. Journal of the American Heart Association, 11(14), e024675. https://doi.org/10.1161/JAHA.122.024675 | |
| Language | Dutch; English |
| Contributor | Data Manager : Neha Moopen |
| Funding Information | Elisabeth von Freyburg Stichting: UMC/WKZ 23-01 “Young at Heart” |
| Depositor | van der Linden, Isabelle |
| Deposit Date | 2024-11-08 |
| Time Period | Start Date: 2024-02-01 ; End Date: 2029-02-01 |
| Date of Collection | Start Date: 2024-08-01 ; End Date: 2029-02-01 |
| Data Type | Clinical data; Survey data |
| Software | R, Version: 4.2 |
Dataset Terms
| License/Data Use Agreement | Our Community Norms as well as good scientific practices expect that proper credit is given via citation. Please use the data citation shown on the dataset page. Custom Dataset Terms — the following Custom Dataset Terms have been defined for this dataset. |
| Terms of Use | The standard Data Sharing Agreement (DSA) of the UMC Utrecht must be signed without adjustments. This DSA is in compliance with Dutch law. No costs are involved. |
| Confidentiality Declaration | No confidentiality declaration needed under the condition that Terms of Use are met. |
| Special Permissions | To obtain access to the data, a request form has to be completed. Only if your request is approved, in addition to a completed request form, a Data Sharing Agreement (DSA) in line with GDPR regulations and/or a Research Collaboration Agreement (RCA) should be signed before data is shared. Only data requests in line with the Terms of Use will be taken into consideration. |
| Restrictions | Read here for more information about the data request proces and the Data Sharing Agreement. The Data Sharing Agreement is signed by both parties. |
| Citation Requirements | Read here for more information about the data request proces and the Data Sharing Agreement. The Data Sharing Agreement is signed by both parties. |
| Conditions | To access and use the dataset please read the Terms of Use and the Terms of Access for Restricted Files. |
| Disclaimer | Read here for more information about the data request proces and the Data Sharing Agreement. The Data Sharing Agreement is signed by both parties. |